Radiation Causes Stem Cell Dysfunction

Adult Stem cells, the little amazing (re)creation cells, have been shown to become dysfunctional when exposed to radiation.  The reason this research paper is so interesting is because of the amount of radiation we are exposed to every day from airport scanners, to actually flying in the air, to wifi, computers, cell phones, and GPS systems.  When radiologists were consulted, they concluded that the average person has more exposure to radiation in daily life than therapeutic doses of radiation in a medical setting.

Charles L. Limoli, Erich Giedzinski, Radoslaw Rola, Shinji Otsuka, Theo D. Palmer, and John R. Fike conducted separate studies from various universities on the effect of radiation on stem cells.  The research paper titled, Radiation Response of Neural Precursor Cells: Linking Cellular Sensitivity to Cell Cycle Checkpoints, Apoptosis and Oxidative Stressno access is abstracted here:

“Therapeutic irradiation of the brain can cause a progressive cognitive dysfunction that may involve defects in neurogenesis. In an effort to understand the mechanisms underlying radiation-induced stem cell dysfunction, neural precursor cells isolated from the adult rat hippocampus were analyzed for acute (0–24 h) and chronic (3–33 days) changes in apoptosis and reactive oxygen species (ROS) after exposure to X rays. Irradiated neural precursor cells exhibited an acute dose-dependent apoptosis accompanied by an increase in ROS that persisted over a 3–4-week period. The radiation effects included the activation of cell cycle checkpoints that were associated with increased Trp53 phosphorylation and Trp53 and p21 (Cdkn1a) protein levels. In vivo, neural precursor cells within the hippocampal dentate subgranular zone exhibited significant sensitivity to radiation. Proliferating precursor cells and their progeny (i.e. immature neurons) exhibited dose-dependent reductions in cell number. These reductions were less severe in Trp53-null mice, possibly due to the disruption of apoptosis. These data suggest that the apoptotic and ROS responses may be tied to Trp53-dependent regulation of cell cycle control and stress-activated pathways. The temporal coincidence between in vitro and in vivo measurements of apoptosis suggests that oxidative stress may provide a mechanistic explanation for radiation-induced inhibition of neurogenesis in the development of cognitive impairment.”

The bottom line of this research paper?  Radiation Causes Stem Cell Dysfunction and Cellular die-off.  Very scary news indeed.

Stem Cells From Sperm Offers New Treatment For Male Infertility

Most people only hear of embryonic, fetal, cord blood stem cells, or bone marrow stem cells.  Stem cells are actually produced throughout the body.  One interesting place that stem cells are very prolific, and makes the most sense concerning the beginning of life, is the male testes (i.e. sperm stem cells). Here is a medical … Continue reading

How to Handle Potential Infections in Stem Cell Research

Anytime you are dealing with human or animal tissue, there is the danger of infection or the spreading of disease. In Spain they have been working on this issue for years and there is a paper by Fernando Cobo of the Stem Cell Bank of Andalucía in which he addresses this issue. Here is a … Continue reading

Breast Cell Found To Have Stem Cell Like Capabilities Of Producing Cancer

Stem cell – like cells can be turned cancerous in breast tissue.  Researchers from Michigan State University characterized two types of breast epithelial cell types, with one type possessing the ability to become mutinous under certain conditions because these particular cells exhibit stem cell-like characteristics that can turn into breast cancer. The epithelial cells make … Continue reading

Amnionic Fluid-Another Source For Stem Cells

Fetal stem cells have been another source of controversy through the years.  Some people disagree with using a fetus for stem cell research.  Several factors are involved in the controversy.  Aborted fetuses, via abortion, were used at one time for a source of fetal stem cells.  Unplanned miscarriages are another source.  These avenues evokes many … Continue reading

Stem Cell Research Pros and Cons

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Stem Cells that Live Forever… from Human Hair

Here is a quick overview from a group of scientists in Massachusetts (Beth Israel Deaconess Medical Center and University of Mass Medical School) explaining how they were able to derive “immortal” stem cells from human hair follicles: _____________________________________ Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles By: Cecilia Roha, … Continue reading

What Are Stem Cells?

Stems cells are very special cells that, when told what to do, can turn into any type of cell  in the body.  The healthy stem cells are signaled to go to a particular area of the body needing regeneration.  The new stem cells replace the damaged or worn out cells and then begin to function … Continue reading

Stem Cells for Dogs

Just when you thought you have heard everything, something new has popped into the scene.  Stem cell therapy for you pet.  While this may sound wacky, this really is an amazing lifesaver to many animals.  Often even saving the owner money in the long run. If you own a pet, then you know that many … Continue reading

Stem Cell Research Pros

Stem cell research pros has shown us that stem cells are special cells which, when given specialized signal, can become any part of the body needed for regeneration.  The body may need muscle cells, blood cells, skin cells, organ cells, nervous system cells, etc.  The stem cells will go in and sweep up the cells … Continue reading