Stem cell – like cells can be turned cancerous in breast tissue. Researchers from Michigan State University characterized two types of breast epithelial cell types, with one type possessing the ability to become mutinous under certain conditions because these particular cells exhibit stem cell-like characteristics that can turn into breast cancer.
The epithelial cells make up our skin and also surround our glands and body cavity.
Chia-Cheng Chang, Wei Sun, Angela Cruz, Maki Saitoh, Mei-Hui Tai, and James E. Trosko reported these findings in, A Human Breast Epithelial Cell Type with Stem Cell Characteristics as Target Cells for Carcinogenesis.
The abstract of this research will be included here:
“Two types of human breast epithelial cells (HBEC) have been characterized. In contrast to Type II HBEC, which express basal epithelial cell phenotypes, Type I HBEC are deficient in gap junctional intercellular communication and are capable of anchorage-independent growth and of expressing luminal epithelial cell markers, estrogen receptors, and stem cell characteristics (i.e. the ability to differentiate into other cell types and to form budding/ductal organoids on Matrigel). A comparative study of these two types of cells has revealed a high susceptibility of Type I HBEC to immortalization by SV40 large T antigen, although both types of cells are equally capable of acquiring an extended life span (bypassing senescence) after transfection with SV40. The immortalization was accompanied by elevation of a low level of telomerase activity in the parental cells after mid-passage (60 cumulative population doubling levels). Thus HBEC do have a low level of telomerase activity, and Type I HBEC with stem cell characteristics are more susceptible to telomerase activation and immortalization, a mechanism which might qualify them as target cells for breast carcinogenesis. The immortalized Type I HBEC can be converted to highly tumorigenic cells by further treatment with X rays (2 Gy × 2) and transfection with a mutated ERBB2 (also known as NEU) oncogene, resulting in the expression of p185ERBB2 which is tyrosine phosphorylated.”
Telomerase activity explains how many times a cell can renew itself before dying completely. An extended telomerase means the cell has a longer than normal life and can then become cancerous. Cancer cells have long telomerase.
Neural stem cells are not only abundant in humans forming in the womb but in adult humans as well. Fred H. Gage, from The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA., identified the many neural stem cells present in the human brain. The paper titled: “Mammalian Neural Stem Cells” … Continue reading
Fetal stem cells have been another source of controversy through the years. Some people disagree with using a fetus for stem cell research. Several factors are involved in the controversy. Aborted fetuses, via abortion, were used at one time for a source of fetal stem cells. Unplanned miscarriages are another source. These avenues evokes many … Continue reading
Most people have heard of the possibilities that embryonic stem cell therapies have been promoting. Up to the last decade or so, people considered embryonic stem cells the only source of cells that can turn into any tissue in the body. Mesenchymal cells that are found in the blood marrow of adults show similar capabilities … Continue reading
Stems cells are very special cells that, when told what to do, can turn into any type of cell in the body. The healthy stem cells are signaled to go to a particular area of the body needing regeneration. The new stem cells replace the damaged or worn out cells and then begin to function … Continue reading
Just when you thought you have heard everything, something new has popped into the scene. Stem cell therapy for you pet. While this may sound wacky, this really is an amazing lifesaver to many animals. Often even saving the owner money in the long run. If you own a pet, then you know that many … Continue reading
Like everything in life, stem cell research is not exempt from having both pros and cons. Let’s look at some aspects about stem cell research pros and cons that are of particular interest and usefulness to anyone interested in the subject of stem cells. Stem cell research has been shrouded in controversy as people fight … Continue reading
Good news for Stroke patients! Research shows that stem cells continue to produce neurons after a stroke to aid in the regeneration of the brain. “Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke” is a paper written by Pär Thored, et al, at the Laboratory of Neurogenesis and Cell Therapy, … Continue reading
Stem cell research pros has shown us that stem cells are special cells which, when given specialized signal, can become any part of the body needed for regeneration. The body may need muscle cells, blood cells, skin cells, organ cells, nervous system cells, etc. The stem cells will go in and sweep up the cells … Continue reading
Many people wonder what the best source of mesenchymal stem cells is: Bone marrow? Umbilical cord blood? Adipose or fat? Let’s look at the findings of Susan Kern, et al, from the Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden-Württemberg–Hessen, Mannheim, Germany. In a paper titled: “Comparative Analysis of Mesenchymal … Continue reading