Stem cell – like cells can be turned cancerous in breast tissue. Researchers from Michigan State University characterized two types of breast epithelial cell types, with one type possessing the ability to become mutinous under certain conditions because these particular cells exhibit stem cell-like characteristics that can turn into breast cancer.
The epithelial cells make up our skin and also surround our glands and body cavity.
Chia-Cheng Chang, Wei Sun, Angela Cruz, Maki Saitoh, Mei-Hui Tai, and James E. Trosko reported these findings in, A Human Breast Epithelial Cell Type with Stem Cell Characteristics as Target Cells for Carcinogenesis.
The abstract of this research will be included here:
“Two types of human breast epithelial cells (HBEC) have been characterized. In contrast to Type II HBEC, which express basal epithelial cell phenotypes, Type I HBEC are deficient in gap junctional intercellular communication and are capable of anchorage-independent growth and of expressing luminal epithelial cell markers, estrogen receptors, and stem cell characteristics (i.e. the ability to differentiate into other cell types and to form budding/ductal organoids on Matrigel). A comparative study of these two types of cells has revealed a high susceptibility of Type I HBEC to immortalization by SV40 large T antigen, although both types of cells are equally capable of acquiring an extended life span (bypassing senescence) after transfection with SV40. The immortalization was accompanied by elevation of a low level of telomerase activity in the parental cells after mid-passage (60 cumulative population doubling levels). Thus HBEC do have a low level of telomerase activity, and Type I HBEC with stem cell characteristics are more susceptible to telomerase activation and immortalization, a mechanism which might qualify them as target cells for breast carcinogenesis. The immortalized Type I HBEC can be converted to highly tumorigenic cells by further treatment with X rays (2 Gy × 2) and transfection with a mutated ERBB2 (also known as NEU) oncogene, resulting in the expression of p185ERBB2 which is tyrosine phosphorylated.”
Telomerase activity explains how many times a cell can renew itself before dying completely. An extended telomerase means the cell has a longer than normal life and can then become cancerous. Cancer cells have long telomerase.
Fetal stem cells have been another source of controversy through the years. Some people disagree with using a fetus for stem cell research. Several factors are involved in the controversy. Aborted fetuses, via abortion, were used at one time for a source of fetal stem cells. Unplanned miscarriages are another source. These avenues evokes many … Continue reading
Many people wonder what the best source of mesenchymal stem cells is: Bone marrow? Umbilical cord blood? Adipose or fat? Let’s look at the findings of Susan Kern, et al, from the Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden-Württemberg–Hessen, Mannheim, Germany. In a paper titled: “Comparative Analysis of Mesenchymal … Continue reading
Like everything in life, stem cell research is not exempt from having both pros and cons. Let’s look at some aspects about stem cell research pros and cons that are of particular interest and usefulness to anyone interested in the subject of stem cells. Stem cell research has been shrouded in controversy as people fight … Continue reading
Have you ever wondered how stem cells injected into the body know precisely where to go in the body for healing and regeneration? Here is an abstract from Giselle Chamberlain, et al, from Leopold Muller Arthritis Research Centre, School of Medicine, Keele University, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shrops, United Kingdom. The … Continue reading
The first step to considering stem cell therapy is to know why you want stem cell therapy. Some people want stem cell therapy to help their body fight a disease, such as cancer, heart disease, or diabetes. Some people want stem cell therapy for the anti-aging principals. They would like a reduction in pain and … Continue reading
Many people hear the term stem cell, but rarely understand what a stem cell is. Usually jargon used in the stem cell research field is muddled with scientific vocabularly that leaves the average person wondering what the researchers had just said. This paper, outlining the mechanisms of a stem cell in an unusual work of … Continue reading
There is a new breakthrough in hair loss for men and women. Hair loss has usually been the bane of men’s existence but few people realize the trauma that women endure when they are also the benefactor of hair thinning or hair loss. Many people have tried the hair grow shampoos, the special combs, and … Continue reading
Adult Stem cells, the little amazing (re)creation cells, have been shown to become dysfunctional when exposed to radiation. The reason this research paper is so interesting is because of the amount of radiation we are exposed to every day from airport scanners, to actually flying in the air, to wifi, computers, cell phones, and GPS … Continue reading
Stems cells are very special cells that, when told what to do, can turn into any type of cell in the body. The healthy stem cells are signaled to go to a particular area of the body needing regeneration. The new stem cells replace the damaged or worn out cells and then begin to function … Continue reading